Acid-Base Disorders (Mara Nitu, MD)
Objectives After completing this article, readers should be able to:
1. Understand the mechanisms for regulating acid-base physiology.
2. Know the differential diagnosis of metabolic acidosis associated with high anion gap
and plan for initial management.
3. Know the differential diagnosis of normal anion gap metabolic acidosis.
4. Describe pulmonary compensatory changes in metabolic acidosis and alkalosis.
5. Understand how various diuretics can lead to acid-base imbalance.
6. Describe renal compensatory changes in respiratory acidosis and alkalosis.
Objectives After completing this article, readers should be able to:
1. Understand the mechanisms for regulating acid-base physiology.
2. Know the differential diagnosis of metabolic acidosis associated with high anion gap
and plan for initial management.
3. Know the differential diagnosis of normal anion gap metabolic acidosis.
4. Describe pulmonary compensatory changes in metabolic acidosis and alkalosis.
5. Understand how various diuretics can lead to acid-base imbalance.
6. Describe renal compensatory changes in respiratory acidosis and alkalosis.


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