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The influence of mixing time and colloidal silica on the lubricating properties of magnesium stearate
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The influence of mixing time and colloidal silica on the lubricating properties of magnesium stearate was studied using an instrumented single-punch machine. The lubricant was mixed with sodium chloride, anhydrous lactose, calcium citrate granulate and sodium chloride-colloidal silica-mixtures.
Short mixing time decreased the negative effects of magnesium stearate on tablet strength and disintegration without reducing the lubricating efficiency. Addition of colloidal silica had a positive effect on the strength of lubricated sodium chloride tablets but increased the friction and did not improve the disintegration.
The influence of mixing time and colloidal silica on the lubricating properties of magnesium stearate was studied using an instrumented single-punch machine. The lubricant was mixed with sodium chloride, anhydrous lactose, calcium citrate granulate and sodium chloride-colloidal silica-mixtures.
Short mixing time decreased the negative effects of magnesium stearate on tablet strength and disintegration without reducing the lubricating efficiency. Addition of colloidal silica had a positive effect on the strength of lubricated sodium chloride tablets but increased the friction and did not improve the disintegration.
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